{
  "evidence_kind": "Observed patient-linked pilot-study endpoint patterns, not complete pulp regeneration",
  "patient_registry": {
    "enrolled": 5,
    "one_affected_tooth_per_patient": true,
    "screened_or_approached": null,
    "Table4_24wk_EPT_status_records": 5,
    "Table4_24wk_apical_MRI_values": 5,
    "Table4_24wk_XR_symbols": 5,
    "unambiguous_binary_XR_radiolucency_states": 4,
    "Table4_CBCT_flags_with_unspecified_visit": 5,
    "same_unit_numeric_CBCT_volume_pairs": 1,
    "reported_formal_dropout_flow": null,
    "complete36wk_cohort_inferred": false
  },
  "EPT_source_status_counts": {
    "onset_EPT_table4": {
      "denominator_enrolled_patients": 5,
      "observed_pattern_patient_ids": [
        "1",
        "3",
        "4",
        "5"
      ],
      "observed_not_pattern_patient_ids": [
        "2"
      ],
      "unknown_patient_ids": [],
      "count_bounds": [
        4,
        4
      ],
      "proportion_bounds": [
        0.8,
        0.8
      ],
      "meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
    },
    "EPT_12wk_table4": {
      "denominator_enrolled_patients": 5,
      "observed_pattern_patient_ids": [
        "1",
        "3",
        "4",
        "5"
      ],
      "observed_not_pattern_patient_ids": [
        "2"
      ],
      "unknown_patient_ids": [],
      "count_bounds": [
        4,
        4
      ],
      "proportion_bounds": [
        0.8,
        0.8
      ],
      "meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
    },
    "EPT_24wk_table4": {
      "denominator_enrolled_patients": 5,
      "observed_pattern_patient_ids": [
        "1",
        "3",
        "4",
        "5"
      ],
      "observed_not_pattern_patient_ids": [
        "2"
      ],
      "unknown_patient_ids": [],
      "count_bounds": [
        4,
        4
      ],
      "proportion_bounds": [
        0.8,
        0.8
      ],
      "meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
    }
  },
  "EPT_reading_audit": {
    "nested_device_readings": 36,
    "independent_patients": 5,
    "right_censored_readings": [
      {
        "patient_id": "4",
        "source_endpoint": "onset_EPT_table4",
        "source_token": "80+"
      },
      {
        "patient_id": "5",
        "source_endpoint": "onset_EPT_table4",
        "source_token": "80+"
      }
    ],
    "changed_control_tooth_patient_ids": [
      "1",
      "3",
      "4"
    ],
    "normalized_longitudinal_sensory_recovery_percent": null,
    "interpretation": "Source categorical positivity only; device units are not linear nerve function. No averaging80+ as80 or averaging across changing control teeth."
  },
  "MRI_24wk_apical_signal": {
    "patient_values": [
      {
        "patient_id": "1",
        "relative_signal": 0.8
      },
      {
        "patient_id": "2",
        "relative_signal": 0.9
      },
      {
        "patient_id": "3",
        "relative_signal": 0.9
      },
      {
        "patient_id": "4",
        "relative_signal": 0.7
      },
      {
        "patient_id": "5",
        "relative_signal": 0.9
      }
    ],
    "source_ratio_definition": "Ratio of root-canal tissue signal to surrounding dentin, compared with normal pulp/dentin in the opposite site; apical Table4 values only. No healthy threshold adopted.",
    "mean": 0.84,
    "median": 0.9,
    "minimum": 0.7,
    "maximum": 0.9,
    "source_defined_healthy_threshold": null,
    "direct_blood_flow": null,
    "native_pulp_identity_confirmed": null,
    "interpretation": "Continuous relative image signal, not perfusion, normal-tissue equivalence or a histological identity test"
  },
  "linked_measured_patterns": {
    "EPT_positive_at_both12_and24_weeks": {
      "denominator_enrolled_patients": 5,
      "observed_pattern_patient_ids": [
        "1",
        "3",
        "4",
        "5"
      ],
      "observed_not_pattern_patient_ids": [
        "2"
      ],
      "unknown_patient_ids": [],
      "count_bounds": [
        4,
        4
      ],
      "proportion_bounds": [
        0.8,
        0.8
      ],
      "meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
    },
    "24wk_EPT_positive_and_MRI_value_available": {
      "denominator_enrolled_patients": 5,
      "observed_pattern_patient_ids": [
        "1",
        "3",
        "4",
        "5"
      ],
      "observed_not_pattern_patient_ids": [
        "2"
      ],
      "unknown_patient_ids": [],
      "count_bounds": [
        4,
        4
      ],
      "proportion_bounds": [
        0.8,
        0.8
      ],
      "meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
    },
    "24wk_MRI_value_available_and_unambiguous_XR_radiolucency_absence": {
      "denominator_enrolled_patients": 5,
      "observed_pattern_patient_ids": [
        "1",
        "3",
        "5"
      ],
      "observed_not_pattern_patient_ids": [
        "4"
      ],
      "unknown_patient_ids": [
        "2"
      ],
      "count_bounds": [
        3,
        4
      ],
      "proportion_bounds": [
        0.6,
        0.8
      ],
      "meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
    },
    "24wk_EPT_positive_MRI_value_available_and_unambiguous_XR_radiolucency_absence": {
      "denominator_enrolled_patients": 5,
      "observed_pattern_patient_ids": [
        "1",
        "3",
        "5"
      ],
      "observed_not_pattern_patient_ids": [
        "2",
        "4"
      ],
      "unknown_patient_ids": [],
      "count_bounds": [
        3,
        3
      ],
      "proportion_bounds": [
        0.6,
        0.6
      ],
      "meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
    },
    "24wk_EPT_positive_with_XR_radiolucency_present": {
      "denominator_enrolled_patients": 5,
      "observed_pattern_patient_ids": [
        "4"
      ],
      "observed_not_pattern_patient_ids": [
        "1",
        "2",
        "3",
        "5"
      ],
      "unknown_patient_ids": [],
      "count_bounds": [
        1,
        1
      ],
      "proportion_bounds": [
        0.2,
        0.2
      ],
      "meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
    }
  },
  "MRI_availability_in_patterns": "All5 have a numeric Table4 ratio. Availability is not an MRI-positive or physiological-success classification.",
  "discordant_patient_records": [
    {
      "patient_id": "2",
      "EPT_24wk_positive": false,
      "apical_MRI_ratio": 0.9,
      "XR_radiolucency": "Unresolved minus/plus, shrinking prior lesion and widened PDL; not coded absent",
      "late_EPT": "After36weeks footnote only; exact time and complete later cohort unavailable"
    },
    {
      "patient_id": "4",
      "EPT_24wk_positive": true,
      "apical_MRI_ratio": 0.7,
      "XR_radiolucency": "Present at24weeks following PDL widening at12weeks; no causal attribution computed",
      "CBCT": "Positive lateral-mineralization flag at an unassigned Table4 visit; not a24-week joint criterion"
    }
  ],
  "CBCT_separate_source_flags": {
    "reported_lateral_mineralization_patient_ids": [
      "1",
      "4",
      "5"
    ],
    "denominator_enrolled_patients": 5,
    "exact_visit_in_Table4": null,
    "native_dentin_or_mechanical_strength_confirmed": null,
    "volume_audits": [
      {
        "patient_id": "1",
        "before_value": 0.0143,
        "before_unit_literal": "cm3",
        "after_value": 0.0125,
        "after_unit_literal": "cm3",
        "results_narrative_times_weeks": [
          16,
          28
        ],
        "timing_qualification": "Results narrative16/28weeks; no individual acquisition dates given",
        "endpoint": "CBCT threshold-defined low-density pulp-space volume, not direct tissue mass, perfusion or histological dentin volume",
        "eligible_for_24wk_joint_pattern": false,
        "status": "same_unit_printed_pair",
        "decrease_value": 0.0017999999999999995,
        "decrease_fraction": 0.12587412587412583
      },
      {
        "patient_id": "4",
        "before_value": 0.011,
        "before_unit_literal": "cm3",
        "after_value": 0.0081,
        "after_unit_literal": "m3",
        "results_narrative_times_weeks": [
          16,
          28
        ],
        "timing_qualification": "Figure3b labels16 and28/32weeks; patient4 Discussion instead mentions12/24weeks",
        "endpoint": "CBCT threshold-defined low-density pulp-space volume, not direct tissue mass, perfusion or histological dentin volume",
        "eligible_for_24wk_joint_pattern": false,
        "status": "source_unit_conflict",
        "decrease_value": null,
        "decrease_fraction": null,
        "interpretation": "No unit repair or conditional change computed; source unit/time conflicts remain unresolved"
      }
    ],
    "missing_initial_CBCT_patient5": true,
    "cohort_mean_volume_change": null
  },
  "safety_and_limits": {
    "source_reports_no_attributed_systemic_or_clinical_events_through24wk": true,
    "source_lab_clinical_abnormality_symbols": {
      "1": {
        "Blood test": "\u2013",
        "Urine test": "\u2013",
        "Cardiogram": "\u2013",
        "Local clinical examination": "\u2013"
      },
      "2": {
        "Blood test": "\u2013",
        "Urine test": "\u2013",
        "Cardiogram": "\u2013",
        "Local clinical examination": "\u2013"
      },
      "3": {
        "Blood test": "\u2013",
        "Urine test": "\u2013",
        "Cardiogram": "\u2013",
        "Local clinical examination": "\u2013"
      },
      "4": {
        "Blood test": "\u2013",
        "Urine test": "\u2013",
        "Cardiogram": "\u2013",
        "Local clinical examination": "\u2013"
      },
      "5": {
        "Blood test": "\u2013",
        "Urine test": "\u2013",
        "Cardiogram": "\u2013",
        "Local clinical examination": "\u2013"
      }
    },
    "new_patient4_radiographic_abnormality_preserved": true,
    "cell_karyotype_patterns_not_all_declared_normal": true,
    "long_term_safety_proven": false,
    "controlled_treatment_effect": null,
    "full_regeneration_success_count": null,
    "directly_measured_perfusion_or_human_pulp_histology_n": 0
  }
}