{ "schema_version": 1, "source_revision": "e650b997c3155439f748fb85f15f03ead6bb19a4", "count": 20, "updates": [ { "id": "restoration-goals", "title": "The full restoration goals", "topic": "Whole-body restoration", "updated_on": "2026-10-22", "evidence_kind": "research_plan", "result": "Restore natural tooth substance and form, gums, living attachment, sensation and stable position after temporary support; pursue durable youthful function throughout the body.", "boundary": "These are research objectives. Photos constrain visible form but do not uniquely recover hidden tooth thickness or internal damage.", "next_step": "Keep every required tissue and function visible when choosing a narrower experiment.", "evidence_label": "Research objectives and plan", "artifacts": [ { "id": "goals", "label": "Read the goals", "path": "studies/restoration-run-plan-2026-10-11/GOALS_AND_CONTINUITY.md", "sha256_lf_text": "8210181e03654ccbe0c1c539bac2997d504447ca150f175462ca2eb29558771a", "bytes_utf8_lf": 8468, "reader": "artifacts/restoration-goals/goals.html", "download": "artifacts/restoration-goals/goals.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/restoration-run-plan-2026-10-11/GOALS_AND_CONTINUITY.md" }, { "id": "plan", "label": "Read the run plan", "path": "studies/restoration-run-plan-2026-10-11/PLAN.md", "sha256_lf_text": "33848b22f89f06ea8557408cee6478bbc8a34ce83eb2a5e37831012e0ac8ba9c", "bytes_utf8_lf": 36355, "reader": "artifacts/restoration-goals/plan.html", "download": "artifacts/restoration-goals/plan.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/restoration-run-plan-2026-10-11/PLAN.md" } ] }, { "id": "mechanics-spatial-root-support", "title": "Support location and crown contact change the model response", "topic": "Dental restoration", "updated_on": "2026-10-22", "evidence_kind": "illustrative_model", "result": "Executed 30 support/contact cases with force, moment and energy checks. Equal support-length loss gives different compliance; two manufactured support distributions share the whole global stiffness matrix while local forces differ.", "boundary": "Every length, stiffness and load is illustrative. The rigid crown does not model restored enamel thickness, biological healing, human mobility thresholds or stable position after support withdrawal.", "next_step": "Qualify root/socket geometry and spatial deformation or structural measurements alongside global response before fitting a tissue-specific model.", "evidence_label": "Illustrative model", "artifacts": [ { "id": "report", "label": "Read the spatial mechanics study", "path": "studies/checklist-engineering-2026-10-22/mechanics/REPORT.md", "sha256_lf_text": "aca22e9e79de439b289db80a27834214e10309d0fe6b1dbb4f966c85c4ebf66b", "bytes_utf8_lf": 11931, "reader": "artifacts/mechanics-spatial-root-support/report.html", "download": "artifacts/mechanics-spatial-root-support/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-engineering-2026-10-22/mechanics/REPORT.md" }, { "id": "results", "label": "See all model results and checks", "path": "studies/checklist-engineering-2026-10-22/mechanics/derived/results.json", "sha256_lf_text": "b8ff31b34ad83c1d6d3144fc1e3fe16628b86dfcf8183d29f3b0c50cfc9e9559", "bytes_utf8_lf": 97614, "reader": "artifacts/mechanics-spatial-root-support/results.html", "download": "artifacts/mechanics-spatial-root-support/results.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-engineering-2026-10-22/mechanics/derived/results.json" } ] }, { "id": "oral-model-separate-measurements", "title": "Oral tissue thickness, resistance and tracer transport differ", "topic": "Dental restoration", "updated_on": "2026-10-22", "evidence_kind": "source_data_reanalysis", "result": "For two reported buccal cell-line model conditions, thickness differs 7.543-fold, electrical resistance-area product 1.016-fold and standard FD20 apparent permeability 0.577-fold.", "boundary": "These are aggregate summaries with reported SEM and replicate counts, not paired donor/insert effects. Commercial total thickness includes matrix. The narrowed noninfectious comparison does not establish native gingival restoration.", "next_step": "Link identity, insert and time to geometry, resistance, tracer transport and viability before judging a functional gingival seal.", "evidence_label": "Published data reanalysis", "artifacts": [ { "id": "report", "label": "Read the oral measurement comparison", "path": "studies/checklist-engineering-2026-10-22/barrier/REPORT.md", "sha256_lf_text": "e0097149bce6d63473fac740e5f85c5df3e04b64fa29338d0314f75e7a2c628b", "bytes_utf8_lf": 5211, "reader": "artifacts/oral-model-separate-measurements/report.html", "download": "artifacts/oral-model-separate-measurements/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-engineering-2026-10-22/barrier/REPORT.md" }, { "id": "results", "label": "See descriptive source-summary ratios", "path": "studies/checklist-engineering-2026-10-22/barrier/results.json", "sha256_lf_text": "3f3218bd6349350ba5e7d2eedb6054a33ca0b0f74a39b1611b4797ada314088d", "bytes_utf8_lf": 1375, "reader": "artifacts/oral-model-separate-measurements/results.html", "download": "artifacts/oral-model-separate-measurements/results.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-engineering-2026-10-22/barrier/results.json" } ] }, { "id": "delivery-time-activity-history", "title": "Delivery signals depend on time and reporter history", "topic": "Tissue delivery", "updated_on": "2026-10-22", "evidence_kind": "source_audit_conditional_model", "result": "Compared six printed mouse-study associations: 1-hour and 24-hour qPCR each against a fixed 24-hour reporter. Display-rounded differences stay positive; late organ accumulation can disagree with reporter location.", "boundary": "No new fit, raw paired animal series, intended-cell fraction or repair outcome is supplied. Reporter area retains prior activity, and three image fields do not establish three independent animals. Rounding bounds are not confidence intervals.", "next_step": "Connect animal, intended-cell denominator, molecular cargo scope and activity history to correction and organ function on traceable units.", "evidence_label": "Source audit with conditional calculations", "artifacts": [ { "id": "report", "label": "Read the delivery measurement audit", "path": "studies/checklist-engineering-2026-10-22/delivery/REPORT.md", "sha256_lf_text": "c29a674d076b2715818f63099eec23ec92a211d213f3a6637c190958640b29e0", "bytes_utf8_lf": 7186, "reader": "artifacts/delivery-time-activity-history/report.html", "download": "artifacts/delivery-time-activity-history/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-engineering-2026-10-22/delivery/REPORT.md" }, { "id": "results", "label": "See reported association comparisons", "path": "studies/checklist-engineering-2026-10-22/delivery/results.json", "sha256_lf_text": "57f50f4fc13985381da540871aaa092c86bcc232dd38ba05dc83ae85b8741e53", "bytes_utf8_lf": 3696, "reader": "artifacts/delivery-time-activity-history/results.html", "download": "artifacts/delivery-time-activity-history/results.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-engineering-2026-10-22/delivery/results.json" } ] }, { "id": "pulp-linked-patient-outcomes", "title": "Living-pulp records retain sensory and imaging discordance", "topic": "Dental restoration", "updated_on": "2026-10-19", "evidence_kind": "observational_reanalysis", "result": "Linked all five patients in a human pulp pilot. At 24 weeks, four had positive electric sensibility; three also had unambiguously absent periapical radiolucency. An adverse radiograph coexists with positive sensibility in another patient.", "boundary": "This is an uncontrolled five-patient measured pattern, not a regeneration success rate. MRI signal is not blood flow, late responses stay at their later visit, and CBCT timing/unit conflicts remain unresolved.", "next_step": "Link directly qualified perfusion, sensory response, pulp-space integrity and infection status on the same tooth through longer follow-up.", "evidence_label": "Observational data reanalysis", "artifacts": [ { "id": "report", "label": "Read the patient-linked pulp analysis", "path": "studies/checklist-integration-2026-10-19/pulp/REPORT.md", "sha256_lf_text": "bc3644e2451ab016660bcc5dfc6146cdbc3464f58a5fbf1d8913436734a2cb9d", "bytes_utf8_lf": 8235, "reader": "artifacts/pulp-linked-patient-outcomes/report.html", "download": "artifacts/pulp-linked-patient-outcomes/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-integration-2026-10-19/pulp/REPORT.md" }, { "id": "results", "label": "See the recorded endpoint patterns", "path": "studies/checklist-integration-2026-10-19/pulp/derived/patient_endpoint_summary.json", "sha256_lf_text": "52fd714576717d1da0d6ef63289478ce8ff1e1e4113a89a85cb3ac494aea97ed", "bytes_utf8_lf": 11032, "reader": "artifacts/pulp-linked-patient-outcomes/results.html", "download": "artifacts/pulp-linked-patient-outcomes/results.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-integration-2026-10-19/pulp/derived/patient_endpoint_summary.json" } ] }, { "id": "dentin-aged-interface-data", "title": "Aged interface data still lack measured repair-depth linkage", "topic": "Dental restoration", "updated_on": "2026-10-19", "evidence_kind": "source_data_reanalysis", "result": "Recomputed 200 deposited OCT positions after thermal cycling. Conditional block summaries reproduce all four published SDs; descriptive CHX contrasts point in opposite directions across adhesive modes.", "boundary": "Source blocks lack tooth IDs. OCT enhanced-signal width is a proxy, thermal cycling is distinct from mechanical fatigue, and separate tensile records cannot be joined to nominal repair depth.", "next_step": "Measure actual depth and pre/post-challenge interface behavior on the same identified specimens while retaining adverse failure modes.", "evidence_label": "Published data reanalysis", "artifacts": [ { "id": "report", "label": "Read the interface-data analysis", "path": "studies/checklist-integration-2026-10-19/materials/REPORT.md", "sha256_lf_text": "e8474354a1842e8c893c429daa30cd8376ac15bf6f812307ddc0794229dbf7c2", "bytes_utf8_lf": 8946, "reader": "artifacts/dentin-aged-interface-data/report.html", "download": "artifacts/dentin-aged-interface-data/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-integration-2026-10-19/materials/REPORT.md" }, { "id": "results", "label": "See source summaries and sensitivity", "path": "studies/checklist-integration-2026-10-19/materials/results.json", "sha256_lf_text": "cf50b605932a42f2b77d93df387023e604b8a764fddeccc47ff2297a59003cb8", "bytes_utf8_lf": 9833, "reader": "artifacts/dentin-aged-interface-data/results.html", "download": "artifacts/dentin-aged-interface-data/results.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-integration-2026-10-19/materials/results.json" } ] }, { "id": "genome-clinical-function-coverage", "title": "Clinical function does not identify edited-cell coverage", "topic": "Genome repair", "updated_on": "2026-10-19", "evidence_kind": "observational_reanalysis", "result": "Reconstructed six reported clinical-summary groups, four descriptive contrasts and the short follow-up timeline from the original single-patient CPS1 base-editing report.", "boundary": "One infant, unequal sampling windows, unknown specimen counts and continuing care prevent an isolated causal effect. Liver biopsy was deferred; corrected-cell fractions and any ordinary-aging coverage threshold remain unknown.", "next_step": "Require causal-lesion evidence, relevant-cell coverage and durable organ function for each repair target; keep ordinary-aging target identification separate.", "evidence_label": "Observational data reanalysis", "artifacts": [ { "id": "report", "label": "Read the clinical transfer analysis", "path": "studies/checklist-integration-2026-10-19/genome/REPORT.md", "sha256_lf_text": "785877f0e15f3be2fa27c4ab871ff4c9bc6c1cff4b4949beffb3781c65b5d63b", "bytes_utf8_lf": 6537, "reader": "artifacts/genome-clinical-function-coverage/report.html", "download": "artifacts/genome-clinical-function-coverage/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-integration-2026-10-19/genome/REPORT.md" }, { "id": "results", "label": "See clinical-summary calculations", "path": "studies/checklist-integration-2026-10-19/genome/results.json", "sha256_lf_text": "0acf14d3bc2dd680655183f6f30ec3db01ed87c744fbbeb2dbbac1327ab0e1b6", "bytes_utf8_lf": 5847, "reader": "artifacts/genome-clinical-function-coverage/results.html", "download": "artifacts/genome-clinical-function-coverage/results.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-integration-2026-10-19/genome/results.json" } ] }, { "id": "dental-bulk-interface-function", "title": "Dental bulk resistance and host attachment need separate measurements", "topic": "Dental restoration", "updated_on": "2026-10-19", "evidence_kind": "source_data_reanalysis", "result": "Reanalyzed 14 listed crack-resistance curves, three contact-fatigue traces and three brushing-roughness summary pairs from the HEA workbook. Roughness worsens in all three material summaries.", "boundary": "Listed traces and serial points do not identify independent specimens. Bulk response and the separate delamination traces do not link actual repair thickness to host-interface fatigue or clinical durability.", "next_step": "Connect measured regional thickness, host-junction behavior and retained-tooth damage under repeated loading on the same physical specimen.", "evidence_label": "Published data reanalysis", "artifacts": [ { "id": "report", "label": "Read the material and interface analysis", "path": "studies/checklist-function-2026-10-19/dental/REPORT.md", "sha256_lf_text": "4efcc63d7e01d5912c8dc23fe12fee7b7ab5fdb9fe55a533d909920cbf02c15b", "bytes_utf8_lf": 12595, "reader": "artifacts/dental-bulk-interface-function/report.html", "download": "artifacts/dental-bulk-interface-function/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-function-2026-10-19/dental/REPORT.md" }, { "id": "results", "label": "See the source-derived curve summaries", "path": "studies/checklist-function-2026-10-19/dental/results.json", "sha256_lf_text": "e927ced3e3d9d92d87a4c047e65b47bd4d62cd7a931a7d2fc1a3850d89d13f95", "bytes_utf8_lf": 17496, "reader": "artifacts/dental-bulk-interface-function/results.html", "download": "artifacts/dental-bulk-interface-function/results.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-function-2026-10-19/dental/results.json" } ] }, { "id": "attachment-active-passive-function", "title": "Construct contraction is distinct from native ligament mechanics", "topic": "Dental restoration", "updated_on": "2026-10-19", "evidence_kind": "source_data_reanalysis", "result": "Recomputed 777 micrometers of construct shortening and all six native-human tensile summary rows. Native summary moduli change across coupled force and loading-rate regimes.", "boundary": "Force and shortening in the construct are algebraically linked. Active contraction and passive modulus cannot establish equivalent tissue function, donor-age effects, regenerated bilateral attachment or stable tooth position.", "next_step": "Link donor identity, construct geometry, both mineralized insertion interfaces, passive response and measured recovery before testing age-by-niche effects.", "evidence_label": "Published data reanalysis", "artifacts": [ { "id": "report", "label": "Read the attachment mechanics audit", "path": "studies/checklist-function-2026-10-19/attachment/REPORT.md", "sha256_lf_text": "c524b18f72511f2eeb57aef45d3f18b0c86c5cd4233040d252861fbb784f2fac", "bytes_utf8_lf": 8074, "reader": "artifacts/attachment-active-passive-function/report.html", "download": "artifacts/attachment-active-passive-function/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-function-2026-10-19/attachment/REPORT.md" }, { "id": "results", "label": "See the aggregate mechanical calculations", "path": "studies/checklist-function-2026-10-19/attachment/derived/mechanical_summary_results.json", "sha256_lf_text": "f9fe896ec7c29f3fe3c88905bd45317f6208e6e74541c3e2f2dffac7b2aa4646", "bytes_utf8_lf": 4452, "reader": "artifacts/attachment-active-passive-function/results.html", "download": "artifacts/attachment-active-passive-function/results.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-function-2026-10-19/attachment/derived/mechanical_summary_results.json" } ] }, { "id": "motsc-parent-assay-eligibility", "title": "MOTS-c persistence claims depend on what the assay measures", "topic": "Compound delivery", "updated_on": "2026-10-19", "evidence_kind": "source_audit_conditional_model", "result": "Qualified a primary ELISA/LC-MS disagreement and the K14Q steady-state comparison, preserving its variant-specific plasma calibration. None of the four bounded source contexts qualifies as administered-parent concentration-time PK.", "boundary": "Signal-to-detection-limit scale separation is not true concentration or universal assay failure. One steady-state immunoreactive measurement does not identify intact-parent half-life or oral availability; donor-linked repair data remain unavailable.", "next_step": "Resolve intact administered parent, endogenous background and products, then connect exposure with the intended donor-stratified repair function.", "evidence_label": "Source audit with conditional calculations", "artifacts": [ { "id": "report", "label": "Read the MOTS-c measurement audit", "path": "studies/checklist-function-2026-10-19/motsc/REPORT.md", "sha256_lf_text": "a21488d63305a911ede467385e2bad69c4226c52e1f96a1fd94dbf738b819038", "bytes_utf8_lf": 10075, "reader": "artifacts/motsc-parent-assay-eligibility/report.html", "download": "artifacts/motsc-parent-assay-eligibility/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-function-2026-10-19/motsc/REPORT.md" }, { "id": "results", "label": "See assay and PK eligibility results", "path": "studies/checklist-function-2026-10-19/motsc/results.json", "sha256_lf_text": "3c9865abc7901e1f490fed4def8c87a412a217a1225d5e647d06db3423f20f1a", "bytes_utf8_lf": 12606, "reader": "artifacts/motsc-parent-assay-eligibility/results.html", "download": "artifacts/motsc-parent-assay-eligibility/results.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-function-2026-10-19/motsc/results.json" } ] }, { "id": "dental-real-linkage", "title": "48 teeth, with unresolved specimen identities", "topic": "Dental restoration", "updated_on": "2026-10-19", "evidence_kind": "source_data_reanalysis", "result": "Analyzed 384 optical-margin rows and 48 fracture records. Thirty-seven teeth have internally consistent links; adverse joint-outcome bounds retain all 48.", "boundary": "Eleven teeth have identity uncertainty. Deposited low load and blank margin fields stay unchanged. Preparation depth is nominal; these are extracted restored teeth, not regenerated tissue.", "next_step": "Add measured regional repair thickness and valid same-specimen histories while preserving the remaining tooth under loading.", "evidence_label": "Published data reanalysis", "artifacts": [ { "id": "report", "label": "Read the linked-data analysis", "path": "studies/checklist-translation-2026-10-19/dental/REPORT.md", "sha256_lf_text": "7469aa741d310f8870854d817dd672ed97d18d345d0c3b02113beca8a42fb83d", "bytes_utf8_lf": 10574, "reader": "artifacts/dental-real-linkage/report.html", "download": "artifacts/dental-real-linkage/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-translation-2026-10-19/dental/REPORT.md" }, { "id": "links", "label": "See specimen linkage", "path": "studies/checklist-translation-2026-10-19/dental/derived/theisen_specimen_links.tsv", "sha256_lf_text": "27055446d9a247dc0b199dee6315064d410d79801ffe73d23ae7121a25cce955", "bytes_utf8_lf": 4493, "reader": "artifacts/dental-real-linkage/links.html", "download": "artifacts/dental-real-linkage/links.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-translation-2026-10-19/dental/derived/theisen_specimen_links.tsv" } ] }, { "id": "aging-gene-age-support", "title": "Age support changes the gingival trend", "topic": "Aging and youthful function", "updated_on": "2026-10-19", "evidence_kind": "observational_reanalysis", "result": "The full-cohort conflict spans nearly every fixed ECM gene. Restricting the bulk cohort to younger ages reverses its direction; shared-decade analysis preserves the earlier opposition.", "boundary": "The common-span restriction removes every bulk donor over 45. These subsets are not matched-age or matched-donor validation, and expression is not restored function.", "next_step": "Seek matched-donor bulk/cell-resolved measurements with qualified sampling sites and independent functional outcomes.", "evidence_label": "Observational data reanalysis", "artifacts": [ { "id": "report", "label": "Read the gene and age-support challenge", "path": "studies/checklist-translation-2026-10-19/aging/REPORT.md", "sha256_lf_text": "db6677ae1ba19aca3c7bdccf1b53999c814f2956d63b5bc2d3dadeec6ab8a718", "bytes_utf8_lf": 10338, "reader": "artifacts/aging-gene-age-support/report.html", "download": "artifacts/aging-gene-age-support/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-translation-2026-10-19/aging/REPORT.md" }, { "id": "effects", "label": "See all panel effects", "path": "studies/checklist-translation-2026-10-19/aging/derived/fixed_panel_age_effects.tsv", "sha256_lf_text": "8e86aef24a2f43e0a5172afa10783d3a51e292ed92170feec2fe619c1a44fb1d", "bytes_utf8_lf": 6123, "reader": "artifacts/aging-gene-age-support/effects.html", "download": "artifacts/aging-gene-age-support/effects.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-translation-2026-10-19/aging/derived/fixed_panel_age_effects.tsv" } ] }, { "id": "rapamycin-source-selectivity", "title": "Selective signaling has not established reproductive protection", "topic": "Compound selectivity", "updated_on": "2026-10-19", "evidence_kind": "source_data_reanalysis", "result": "Original paired data reproduce DL001 selectivity: 433.38 as the mean of paired ratios, versus 350.24 as the ratio of means. The apparent discrepancy is resolved.", "boundary": "Different assay states, unequal tissue responses and unmatched blood contexts remain. There is no direct DL001 reproductive-protection comparison or established healthy-human testicular-volume inference.", "next_step": "Specify useful function to retain and require same-context relevant-cell exposure plus direct reproductive outcomes.", "evidence_label": "Published data reanalysis", "artifacts": [ { "id": "report", "label": "Read the selectivity analysis", "path": "studies/checklist-translation-2026-10-19/rapamycin/REPORT.md", "sha256_lf_text": "2200ae283af9f832f25f8d932a79d82bcef4ea883ba88d4c92592a1a17bb9738", "bytes_utf8_lf": 14094, "reader": "artifacts/rapamycin-source-selectivity/report.html", "download": "artifacts/rapamycin-source-selectivity/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-translation-2026-10-19/rapamycin/REPORT.md" }, { "id": "results", "label": "See source-derived results", "path": "studies/checklist-translation-2026-10-19/rapamycin/results.json", "sha256_lf_text": "caa70923a2d012b38b1280e932951f57a412884eb721dfd8d05b3bea7db6b354", "bytes_utf8_lf": 5667, "reader": "artifacts/rapamycin-source-selectivity/results.html", "download": "artifacts/rapamycin-source-selectivity/results.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-translation-2026-10-19/rapamycin/results.json" } ] }, { "id": "dental-measured-materials", "title": "What the measured dental material data show", "topic": "Dental restoration", "updated_on": "2026-10-19", "evidence_kind": "source_data_reanalysis", "result": "Recomputed 75 stored source positions. Apparent toughness improves over acid-etched enamel but remains below the native mean; enamel wear directions are unfavorable.", "boundary": "Source positions are not independent donors. Actual repair-depth and interface measurements are not linked to these specimen outcomes.", "next_step": "Find specimen-linked depth, crack, leakage and fatigue observations.", "evidence_label": "Published data reanalysis", "artifacts": [ { "id": "report", "label": "Read analysis", "path": "studies/checklist-followup-2026-10-19/dental/REPORT.md", "sha256_lf_text": "f628218793db7fe5d16e44484ea700d230da86658171e50e968b8570b0393b9e", "bytes_utf8_lf": 10698, "reader": "artifacts/dental-measured-materials/report.html", "download": "artifacts/dental-measured-materials/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-followup-2026-10-19/dental/REPORT.md" }, { "id": "summary", "label": "See material summaries", "path": "studies/checklist-followup-2026-10-19/dental/derived/material_summary.tsv", "sha256_lf_text": "20fa7c1d180ea04000474a3a935b3191c01a7c93f40a6d5561327aa32edc96da", "bytes_utf8_lf": 3394, "reader": "artifacts/dental-measured-materials/summary.html", "download": "artifacts/dental-measured-materials/summary.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-followup-2026-10-19/dental/derived/material_summary.tsv" } ] }, { "id": "dental-linkage-bridge", "title": "Keep dental depth and failures connected", "topic": "Dental restoration", "updated_on": "2026-10-19", "evidence_kind": "software_fixture", "result": "The analysis preserves specimen/tooth/donor nesting, missing leakage and censored fatigue outcomes. The linked examples are synthetic.", "boundary": "The real 75-position source extract supplies zero identifiable linked specimens. Software examples are not regenerated tissue or material performance measurements.", "next_step": "Apply the bridge to an eligible registered specimen series while keeping unknown targets and missing outcomes visible.", "evidence_label": "Analysis software with synthetic examples", "artifacts": [ { "id": "report", "label": "Read the measurement bridge", "path": "studies/checklist-mechanisms-2026-10-19/dental/REPORT.md", "sha256_lf_text": "a370c8199b4071b702da4ac518656dea52ad80a2709a9e8f10a7f6b684561f74", "bytes_utf8_lf": 11074, "reader": "artifacts/dental-linkage-bridge/report.html", "download": "artifacts/dental-linkage-bridge/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-mechanisms-2026-10-19/dental/REPORT.md" }, { "id": "template", "label": "Get an empty measurement packet", "path": "studies/checklist-mechanisms-2026-10-19/dental/measurement_template.json", "sha256_lf_text": "49f2cd7ba08d25e78f73a7588db51d5eab348289d06927b5dbfed80e71883e4e", "bytes_utf8_lf": 379, "reader": "artifacts/dental-linkage-bridge/template.html", "download": "artifacts/dental-linkage-bridge/template.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-mechanisms-2026-10-19/dental/measurement_template.json" } ] }, { "id": "aging-partial-mixture", "title": "Cell composition does not yet explain the age disagreement", "topic": "Aging and youthful function", "updated_on": "2026-10-19", "evidence_kind": "observational_reanalysis", "result": "Structural-ECM age slopes stay positive in observed and common-RNA partial mixtures, opposing the earlier bulk-tissue direction.", "boundary": "The retained groups cover 99.55% of captured cells, but omitted RNA is unknown. This is not reconstructed whole tissue or a biological-age clock.", "next_step": "Read the follow-up gene/age-support challenge, then seek matched-donor bulk and cell-resolved measurements.", "evidence_label": "Observational data reanalysis", "artifacts": [ { "id": "report", "label": "Read the composition challenge", "path": "studies/checklist-mechanisms-2026-10-19/aging/REPORT.md", "sha256_lf_text": "3d2f02e0445e6503b9799b9b627d54a8615e3bfb2bd6570882cda6c9a34abd0d", "bytes_utf8_lf": 12136, "reader": "artifacts/aging-partial-mixture/report.html", "download": "artifacts/aging-partial-mixture/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-mechanisms-2026-10-19/aging/REPORT.md" }, { "id": "effects", "label": "See all age-model results", "path": "studies/checklist-mechanisms-2026-10-19/aging/derived/healthy_age_effects.tsv", "sha256_lf_text": "5ad74a1d3a719ba05be8e4145e83998ba18393ebca7c19f55cd2d8906547ee7a", "bytes_utf8_lf": 15053, "reader": "artifacts/aging-partial-mixture/effects.html", "download": "artifacts/aging-partial-mixture/effects.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-mechanisms-2026-10-19/aging/derived/healthy_age_effects.tsv" } ] }, { "id": "ss31-exposure-material", "title": "SS-31: intact exposure and material accounting", "topic": "Compound delivery", "updated_on": "2026-10-19", "evidence_kind": "source_audit_conditional_model", "result": "Separated intact parent from metabolites, reproduced 21 cellular summaries and bounded oral material needs without assigning oral availability.", "boundary": "Useful cellular access, oral availability and actual manufacturing cost remain unknown. Repeated source values across endpoints are retained as unresolved dependence.", "next_step": "Measure native-parent cellular exposure/function and released-parent process recovery before ranking modifications or delivery approaches.", "evidence_label": "Source audit with conditional calculations", "artifacts": [ { "id": "report", "label": "Read the SS-31 analysis", "path": "studies/checklist-mechanisms-2026-10-19/ss31/REPORT.md", "sha256_lf_text": "fd1b9dd940e2c816d932eda9e7028296fe809c4a56ee8467ce660140526f5c6a", "bytes_utf8_lf": 13842, "reader": "artifacts/ss31-exposure-material/report.html", "download": "artifacts/ss31-exposure-material/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-mechanisms-2026-10-19/ss31/REPORT.md" }, { "id": "results", "label": "See conditional results", "path": "studies/checklist-mechanisms-2026-10-19/ss31/results.json", "sha256_lf_text": "85a2fa1392a0b4ce9eb62f7832df8fe546982b350187918709b0c328862be387", "bytes_utf8_lf": 7480, "reader": "artifacts/ss31-exposure-material/results.html", "download": "artifacts/ss31-exposure-material/results.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-mechanisms-2026-10-19/ss31/results.json" } ] }, { "id": "caffeine-competitive-capture", "title": "Caffeine capture needs capacity as well as binding", "topic": "Caffeine reversal", "updated_on": "2026-10-19", "evidence_kind": "illustrative_model", "result": "A reversible, finite-capacity model uses published buffer affinities to test capture and competition; equimolar host does not imply complete capture.", "boundary": "Chosen buffer concentrations are not human exposures or doses. Paraxanthine capture, oral delivery, brain exchange and sleep recovery are unresolved.", "next_step": "Qualify free-guest binding and intact accessible host in a physiological matrix before interpreting systemic capture.", "evidence_label": "Illustrative model", "artifacts": [ { "id": "report", "label": "Read the capture model", "path": "studies/checklist-mechanisms-2026-10-19/caffeine/REPORT.md", "sha256_lf_text": "7a00691429efaf81f04b4d360279f31169840a3452e3fac914c5d5e4f07d7ebd", "bytes_utf8_lf": 4464, "reader": "artifacts/caffeine-competitive-capture/report.html", "download": "artifacts/caffeine-competitive-capture/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-mechanisms-2026-10-19/caffeine/REPORT.md" }, { "id": "requirements", "label": "See capture requirements", "path": "studies/checklist-mechanisms-2026-10-19/caffeine/derived/target_capture_requirements.tsv", "sha256_lf_text": "2fccd71faab54eef21adb87163b606230e4450af090c3f7fa8789a07b5bf2486", "bytes_utf8_lf": 13083, "reader": "artifacts/caffeine-competitive-capture/requirements.html", "download": "artifacts/caffeine-competitive-capture/requirements.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-mechanisms-2026-10-19/caffeine/derived/target_capture_requirements.tsv" } ] }, { "id": "organoid-measured-function", "title": "Relative spheroid response is not absolute function", "topic": "Organoids and stem cells", "updated_on": "2026-10-19", "evidence_kind": "source_data_reanalysis", "result": "Reconstructed 48 paired insulin observations. The flow/vascular-bed condition has the highest mean relative stimulation index, but not the highest absolute stimulated output.", "boundary": "These are source cell-line spheroids, not patient grafts. Donor, lot and circuit crosswalks are unavailable; the pairs cannot be counted as independent people.", "next_step": "Link perfusion, identity, viability and function on the same constructs with their actual unit hierarchy.", "evidence_label": "Published data reanalysis", "artifacts": [ { "id": "report", "label": "Read the function analysis", "path": "studies/checklist-followup-2026-10-19/organoid/REPORT.md", "sha256_lf_text": "cff240ab19c016a130aec27698652d2886f01d26b4f2d2e7634ac1b2f080892e", "bytes_utf8_lf": 6687, "reader": "artifacts/organoid-measured-function/report.html", "download": "artifacts/organoid-measured-function/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-followup-2026-10-19/organoid/REPORT.md" }, { "id": "summary", "label": "See condition summaries", "path": "studies/checklist-followup-2026-10-19/organoid/derived/condition_summary.tsv", "sha256_lf_text": "e2caf3a76d09a6c46f6be73539fe1ab0f9bbcd0fa18108295eb1d0ab025d84c0", "bytes_utf8_lf": 1162, "reader": "artifacts/organoid-measured-function/summary.html", "download": "artifacts/organoid-measured-function/summary.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-followup-2026-10-19/organoid/derived/condition_summary.tsv" } ] }, { "id": "repair-joint-endpoints", "title": "Separate repair endpoints do not establish joint success", "topic": "Organoids and genome repair", "updated_on": "2026-10-19", "evidence_kind": "illustrative_model", "result": "The joint-endpoint audit shows why separate favorable measurements cannot establish how many units satisfy every required repair condition.", "boundary": "The illustrative endpoint counts are synthetic. Allele, cell and tissue-area denominators cannot be silently combined.", "next_step": "Obtain joint observations with comparable denominators, unit IDs and the relevant functional outcome.", "evidence_label": "Illustrative model", "artifacts": [ { "id": "report", "label": "Read the joint-endpoint audit", "path": "studies/checklist-progress-2026-10-19/integration/REPORT.md", "sha256_lf_text": "3ed343ae58e0194d85b28186316e2cf7d68437290b668c1ce599862609c44a07", "bytes_utf8_lf": 5560, "reader": "artifacts/repair-joint-endpoints/report.html", "download": "artifacts/repair-joint-endpoints/report.txt", "source": "https://github.com/dylanstechmann/regen-workbench/blob/e650b997c3155439f748fb85f15f03ead6bb19a4/studies/checklist-progress-2026-10-19/integration/REPORT.md" } ] } ] }