Aging and youthful function / Observational data reanalysis
See all panel effects
Age support changes the gingival trend
The common-span restriction removes every bulk donor over 45. These subsets are not matched-age or matched-donor validation, and expression is not restored function.
population cohort score_mode model status n_donors rank residual_df maximum_leverage maximum_leverage_donor panel_slope age_min age_max n_positive_gene_slopes n_negative_gene_slopes gene_omission_min gene_omission_max gene_omission_sign_changes donor_omission_min donor_omission_max donor_omission_fits donor_omission_sign_changes donor_omission_failed_fits all_healthy GSE164241 fibroblast_only age_only descriptive_only 13 2 11 0.3782303370786517 health:144 0.17243198235705265 21.0 61.0 8 0 0.16121582813052718 0.18490309598792146 0 0.12507639547518307 0.20720380660390328 13 0 0 all_healthy GSE164241 fibroblast_only age_sex_processing descriptive_only 13 4 9 0.4075957875868251 health:144 0.1860728254030668 21.0 61.0 8 0 0.16818448394590182 0.21231241293326933 0 0.12895279018053218 0.2593969277389524 13 0 0 all_healthy GSE164241 observed_partial_capture age_only descriptive_only 13 2 11 0.3782303370786517 health:144 0.21319860110986363 21.0 61.0 8 0 0.20261606757716502 0.22247109004730356 0 0.1499820461588939 0.27212143657857885 13 0 0 all_healthy GSE164241 observed_partial_capture age_sex_processing descriptive_only 13 4 9 0.4075957875868251 health:144 0.18701555846420004 21.0 61.0 7 1 0.1699451902751808 0.2138808856365995 0 0.11633235619444088 0.28176732979768127 13 0 0 all_healthy GSE164241 common_RNA_partial_capture age_only descriptive_only 13 2 11 0.3782303370786517 health:144 0.1826105929305671 21.0 61.0 8 0 0.171874680768842 0.19186185425207888 0 0.13568114216028232 0.22019079091313878 13 0 0 all_healthy GSE164241 common_RNA_partial_capture age_sex_processing descriptive_only 13 4 9 0.4075957875868251 health:144 0.19236424206188985 21.0 61.0 8 0 0.17477001361490876 0.21898122235093684 0 0.1353104660947159 0.2686974335520466 13 0 0 all_healthy GSE173078 bulk_gingiva age_only descriptive_only 12 2 10 0.3535793105591993 AC050 -0.14529452353740657 28.0 75.0 1 7 -0.16687393275307247 -0.12484881480599068 0 -0.19925041231581467 -0.028952190413881897 12 0 0 all_healthy GSE173078 bulk_gingiva age_sex_processing descriptive_only 12 4 8 0.5057133973337491 AC022 -0.23621158253818497 28.0 75.0 0 8 -0.25197031653917384 -0.22153492249641982 0 -0.29742140934842737 -0.08944365730732975 12 0 0 shared_observed_age_span GSE164241 fibroblast_only age_only descriptive_only 9 2 7 0.44786684522670744 health:144 0.12082845407155182 28.0 61.0 8 0 0.10941328846327665 0.12984745181255886 0 0.06772036339115671 0.15984669884381114 9 0 0 shared_observed_age_span GSE164241 fibroblast_only age_sex_processing descriptive_only 9 4 5 0.544167886774036 health:143 0.15517342830825015 28.0 61.0 8 0 0.14211065071743384 0.16708290798684525 0 0.08156402858492326 0.2253510012218849 9 0 0 shared_observed_age_span GSE164241 observed_partial_capture age_only descriptive_only 9 2 7 0.44786684522670744 health:144 0.12034946023823427 28.0 61.0 8 0 0.1098456263524011 0.13102728088009613 0 0.013239557306056256 0.19628429345029225 9 0 0 shared_observed_age_span GSE164241 observed_partial_capture age_sex_processing descriptive_only 9 4 5 0.544167886774036 health:143 0.08909823228015916 28.0 61.0 7 1 0.07840336368935479 0.1032688814592448 0 -0.08177266310925238 0.2125188943291507 9 2 0 shared_observed_age_span GSE164241 common_RNA_partial_capture age_only descriptive_only 9 2 7 0.44786684522670744 health:144 0.1395025771171685 28.0 61.0 8 0 0.12913969910707632 0.14943816687377057 0 0.1063746000821682 0.17705377248523493 9 0 0 shared_observed_age_span GSE164241 common_RNA_partial_capture age_sex_processing descriptive_only 9 4 5 0.544167886774036 health:143 0.17157368552950003 28.0 61.0 8 0 0.1595248093905278 0.18461780746920425 0 0.09496806953017017 0.2382611610089153 9 0 0 shared_observed_age_span GSE173078 bulk_gingiva age_only descriptive_only 8 2 6 0.5849691531127311 AC018 0.5622688832921104 28.0 45.0 8 0 0.5106033953576709 0.6182068812982129 0 0.42726835904454746 0.669922690268753 8 0 0 shared_observed_age_span GSE173078 bulk_gingiva age_sex_processing descriptive_only 8 4 4 0.8623726947426367 AC018 0.48133888717592477 28.0 45.0 8 0 0.4384997240735037 0.5215127372514329 0 0.19886745506858228 0.6705464832582442 8 0 0 shared_nonempty_decade_bins GSE164241 fibroblast_only age_only descriptive_only 11 2 9 0.7192224622030237 health:144 0.1881618577560122 21.0 61.0 8 0 0.17457134506898922 0.21104615678135938 0 0.1312447084757977 0.23286226613480046 11 0 0 shared_nonempty_decade_bins GSE164241 fibroblast_only age_sex_processing descriptive_only 11 4 7 0.7244626762190897 health:144 0.18928142093095635 21.0 61.0 7 1 0.16955599394101778 0.2298345676536065 0 0.13794331933684756 0.28712514154835117 11 0 0 shared_nonempty_decade_bins GSE164241 observed_partial_capture age_only descriptive_only 11 2 9 0.7192224622030237 health:144 0.1628543462810392 21.0 61.0 8 0 0.14937964074415053 0.18573022781701146 0 0.09541053353334954 0.233212156088952 11 0 0 shared_nonempty_decade_bins GSE164241 observed_partial_capture age_sex_processing descriptive_only 11 4 7 0.7244626762190897 health:144 0.1364511935995004 21.0 61.0 7 1 0.1169537562112631 0.17688537253408768 0 0.058873146229436846 0.27186550880442784 11 0 0 shared_nonempty_decade_bins GSE164241 common_RNA_partial_capture age_only descriptive_only 11 2 9 0.7192224622030237 health:144 0.18209737717972363 21.0 61.0 8 0 0.16815137072757186 0.20454020837002646 0 0.1249686846450332 0.22933773670916136 11 0 0 shared_nonempty_decade_bins GSE164241 common_RNA_partial_capture age_sex_processing descriptive_only 11 4 7 0.7244626762190897 health:144 0.17968538551010238 21.0 61.0 7 1 0.159560668164261 0.21962686183904756 0 0.1271971113592968 0.28034828779032694 11 0 0 shared_nonempty_decade_bins GSE173078 bulk_gingiva age_only descriptive_only 7 2 5 0.3739715189873418 AC016 -0.14420273169287354 28.0 68.0 1 7 -0.17324103893454063 -0.112211724268487 0 -0.24414320040041282 0.03335787570566394 7 1 0 shared_nonempty_decade_bins GSE173078 bulk_gingiva age_sex_processing descriptive_only 7 4 3 0.8000375046880863 AC018 -0.23732995401007062 28.0 68.0 0 8 -0.2610205062592181 -0.21548710391018597 0 -0.27461700650174636 -0.1308669813155895 7 0 0