Aging and youthful function / Observational data reanalysis
See all age-model results
Cell composition does not yet explain the age disagreement
The retained groups cover 99.55% of captured cells, but omitted RNA is unknown. This is not reconstructed whole tissue or a biological-age clock.
panel score_type model n_donors n_female n_male status slope_per_decade rank residual_df max_leverage omission_min omission_max omission_fits omission_sign_changes matrix_degradation observed_partial_RNA_mixture all_healthy_age 13 10 3 descriptive_only 0.15145414305948904 2 11 0.3782303370786517 0.09417823589834298 0.25831876807082943 13 0 matrix_degradation observed_partial_RNA_mixture all_healthy_age_sex_version 13 10 3 descriptive_only 0.09738774930479663 4 9 0.40759578758682535 0.0123195541845465 0.21057903547092652 13 0 matrix_degradation observed_partial_RNA_mixture female_healthy_age_version 10 10 0 descriptive_only 0.10155458318160976 3 7 0.41590561401882165 0 matrix_degradation observed_partial_RNA_mixture strict20_healthy_age 8 5 3 descriptive_only 0.18875222941724792 2 6 0.8291047719205996 0 matrix_degradation observed_partial_RNA_mixture strict20_healthy_age_sex_version 8 5 3 descriptive_only 0.10543750399716403 4 4 0.9427803379416286 0 matrix_degradation common_RNA_weight_partial_mixture all_healthy_age 13 10 3 descriptive_only 0.16267031105701285 2 11 0.3782303370786517 0.12050542161571995 0.2510715668611616 13 0 matrix_degradation common_RNA_weight_partial_mixture all_healthy_age_sex_version 13 10 3 descriptive_only 0.12689343780844364 4 9 0.40759578758682535 0.04751954937587477 0.22586979826119902 13 0 matrix_degradation common_RNA_weight_partial_mixture female_healthy_age_version 10 10 0 descriptive_only 0.1271869664964827 3 7 0.41590561401882165 0 matrix_degradation common_RNA_weight_partial_mixture strict20_healthy_age 8 5 3 descriptive_only 0.17856623590955284 2 6 0.8291047719205996 0 matrix_degradation common_RNA_weight_partial_mixture strict20_healthy_age_sex_version 8 5 3 descriptive_only 0.12586275831327814 4 4 0.9427803379416286 0 matrix_degradation lineage_reference_same_donors all_healthy_age 13 10 3 descriptive_only -0.03293322631884696 2 11 0.3782303370786517 -0.09108611188309343 0.0366242996496883 13 2 matrix_degradation lineage_reference_same_donors all_healthy_age_sex_version 13 10 3 descriptive_only -0.03889783640003924 4 9 0.40759578758682535 -0.11918593248459874 0.057357912743162626 13 2 matrix_degradation lineage_reference_same_donors female_healthy_age_version 10 10 0 descriptive_only -0.04747801980483138 3 7 0.41590561401882165 0 matrix_degradation lineage_reference_same_donors strict20_healthy_age 8 5 3 descriptive_only 0.0005202943117416812 2 6 0.8291047719205996 0 matrix_degradation lineage_reference_same_donors strict20_healthy_age_sex_version 8 5 3 descriptive_only -0.026728822682320408 4 4 0.9427803379416286 0 matrix_inhibitors observed_partial_RNA_mixture all_healthy_age 13 10 3 descriptive_only 0.05574616774436969 2 11 0.3782303370786517 0.02865036614601621 0.0899719862666044 13 0 matrix_inhibitors observed_partial_RNA_mixture all_healthy_age_sex_version 13 10 3 descriptive_only 0.054279603359775316 4 9 0.40759578758682535 0.008870470763936156 0.11733258374591725 13 0 matrix_inhibitors observed_partial_RNA_mixture female_healthy_age_version 10 10 0 descriptive_only 0.048086701562541634 3 7 0.41590561401882165 0 matrix_inhibitors observed_partial_RNA_mixture strict20_healthy_age 8 5 3 descriptive_only 0.006017694996814165 2 6 0.8291047719205996 0 matrix_inhibitors observed_partial_RNA_mixture strict20_healthy_age_sex_version 8 5 3 descriptive_only 0.0078019818995469364 4 4 0.9427803379416286 0 matrix_inhibitors common_RNA_weight_partial_mixture all_healthy_age 13 10 3 descriptive_only 0.020443990432884307 2 11 0.3782303370786517 -0.01160704839434033 0.05018517617206196 13 1 matrix_inhibitors common_RNA_weight_partial_mixture all_healthy_age_sex_version 13 10 3 descriptive_only 0.03990412695079351 4 9 0.40759578758682535 0.007488956740656694 0.09010830207653861 13 0 matrix_inhibitors common_RNA_weight_partial_mixture female_healthy_age_version 10 10 0 descriptive_only 0.03833248159650251 3 7 0.41590561401882165 0 matrix_inhibitors common_RNA_weight_partial_mixture strict20_healthy_age 8 5 3 descriptive_only -0.06390376511686825 2 6 0.8291047719205996 0 matrix_inhibitors common_RNA_weight_partial_mixture strict20_healthy_age_sex_version 8 5 3 descriptive_only -0.03954237831558541 4 4 0.9427803379416286 0 matrix_inhibitors lineage_reference_same_donors all_healthy_age 13 10 3 descriptive_only -0.024280611714178616 2 11 0.3782303370786517 -0.07503780504550871 0.023202755107814686 13 2 matrix_inhibitors lineage_reference_same_donors all_healthy_age_sex_version 13 10 3 descriptive_only -0.02319203464526036 4 9 0.40759578758682535 -0.07431107134128238 0.06792805769586448 13 2 matrix_inhibitors lineage_reference_same_donors female_healthy_age_version 10 10 0 descriptive_only -0.030103446291284183 3 7 0.41590561401882165 0 matrix_inhibitors lineage_reference_same_donors strict20_healthy_age 8 5 3 descriptive_only -0.12878948543667318 2 6 0.8291047719205996 0 matrix_inhibitors lineage_reference_same_donors strict20_healthy_age_sex_version 8 5 3 descriptive_only -0.12237839778406576 4 4 0.9427803379416286 0 structural_ecm observed_partial_RNA_mixture all_healthy_age 13 10 3 descriptive_only 0.21319860110986344 2 11 0.3782303370786517 0.1499820461588938 0.27212143657857873 13 0 structural_ecm observed_partial_RNA_mixture all_healthy_age_sex_version 13 10 3 descriptive_only 0.18701555846420043 4 9 0.40759578758682535 0.11633235619443945 0.2817673297976823 13 0 structural_ecm observed_partial_RNA_mixture female_healthy_age_version 10 10 0 descriptive_only 0.1833646943117436 3 7 0.41590561401882165 0 structural_ecm observed_partial_RNA_mixture strict20_healthy_age 8 5 3 descriptive_only 0.27862431924482745 2 6 0.8291047719205996 0 structural_ecm observed_partial_RNA_mixture strict20_healthy_age_sex_version 8 5 3 descriptive_only 0.2269335888601906 4 4 0.9427803379416286 0 structural_ecm common_RNA_weight_partial_mixture all_healthy_age 13 10 3 descriptive_only 0.18261059293056683 2 11 0.3782303370786517 0.13568114216028232 0.22019079091313862 13 0 structural_ecm common_RNA_weight_partial_mixture all_healthy_age_sex_version 13 10 3 descriptive_only 0.1923642420618898 4 9 0.40759578758682535 0.13531046609471492 0.2686974335520467 13 0 structural_ecm common_RNA_weight_partial_mixture female_healthy_age_version 10 10 0 descriptive_only 0.19740502477530483 3 7 0.41590561401882165 0 structural_ecm common_RNA_weight_partial_mixture strict20_healthy_age 8 5 3 descriptive_only 0.10639804639539252 2 6 0.8291047719205996 0 structural_ecm common_RNA_weight_partial_mixture strict20_healthy_age_sex_version 8 5 3 descriptive_only 0.1007451250568233 4 4 0.9427803379416286 0 structural_ecm lineage_reference_same_donors all_healthy_age 13 10 3 descriptive_only 0.17243198235705254 2 11 0.3782303370786517 0.12507639547518293 0.20720380660390306 13 0 structural_ecm lineage_reference_same_donors all_healthy_age_sex_version 13 10 3 descriptive_only 0.1860728254030673 4 9 0.40759578758682535 0.12895279018053135 0.2593969277389532 13 0 structural_ecm lineage_reference_same_donors female_healthy_age_version 10 10 0 descriptive_only 0.19077354513783829 3 7 0.41590561401882165 0 structural_ecm lineage_reference_same_donors strict20_healthy_age 8 5 3 descriptive_only 0.0746736352097152 2 6 0.8291047719205996 0 structural_ecm lineage_reference_same_donors strict20_healthy_age_sex_version 8 5 3 descriptive_only 0.07456369845505877 4 4 0.9427803379416286 0 inflammation observed_partial_RNA_mixture all_healthy_age 13 10 3 descriptive_only 0.012570088027206987 2 11 0.3782303370786517 -0.04963866225706456 0.0783179701994508 13 3 inflammation observed_partial_RNA_mixture all_healthy_age_sex_version 13 10 3 descriptive_only -0.017652821302599153 4 9 0.40759578758682535 -0.09260126721702622 0.07233167753597564 13 2 inflammation observed_partial_RNA_mixture female_healthy_age_version 10 10 0 descriptive_only -0.012657380448290456 3 7 0.41590561401882165 0 inflammation observed_partial_RNA_mixture strict20_healthy_age 8 5 3 descriptive_only 0.03927154195124765 2 6 0.8291047719205996 0 inflammation observed_partial_RNA_mixture strict20_healthy_age_sex_version 8 5 3 descriptive_only 0.022091990039842524 4 4 0.9427803379416286 0 inflammation common_RNA_weight_partial_mixture all_healthy_age 13 10 3 descriptive_only 0.02845283291062789 2 11 0.3782303370786517 -0.021364225045321816 0.0816602077878841 13 2 inflammation common_RNA_weight_partial_mixture all_healthy_age_sex_version 13 10 3 descriptive_only 0.01931624978836488 4 9 0.40759578758682535 -0.0457309922473802 0.10073176531192218 13 3 inflammation common_RNA_weight_partial_mixture female_healthy_age_version 10 10 0 descriptive_only 0.017944693153156166 3 7 0.41590561401882165 0 inflammation common_RNA_weight_partial_mixture strict20_healthy_age 8 5 3 descriptive_only 0.04386489932157913 2 6 0.8291047719205996 0 inflammation common_RNA_weight_partial_mixture strict20_healthy_age_sex_version 8 5 3 descriptive_only 0.05573525083806541 4 4 0.9427803379416286 0 inflammation lineage_reference_same_donors all_healthy_age 13 10 3 descriptive_only 0.0878480299057185 2 11 0.3782303370786517 -0.026299289043795367 0.15775200907913248 13 1 inflammation lineage_reference_same_donors all_healthy_age_sex_version 13 10 3 descriptive_only 0.046130032309598556 4 9 0.40759578758682535 -0.03857432702535524 0.15204189794623413 13 2 inflammation lineage_reference_same_donors female_healthy_age_version 10 10 0 descriptive_only 0.048544927664673554 3 7 0.41590561401882165 0 inflammation lineage_reference_same_donors strict20_healthy_age 8 5 3 descriptive_only 0.17554342910536608 2 6 0.8291047719205996 0 inflammation lineage_reference_same_donors strict20_healthy_age_sex_version 8 5 3 descriptive_only 0.12574687888403574 4 4 0.9427803379416286 0 epithelial_barrier_identity observed_partial_RNA_mixture all_healthy_age 13 10 3 descriptive_only -0.12209262744056062 2 11 0.3782303370786517 -0.19293039818137922 -0.07040260635716124 13 0 epithelial_barrier_identity observed_partial_RNA_mixture all_healthy_age_sex_version 13 10 3 descriptive_only -0.09872295111866913 4 9 0.40759578758682535 -0.17800044375920196 -0.06533549887271523 13 0 epithelial_barrier_identity observed_partial_RNA_mixture female_healthy_age_version 10 10 0 descriptive_only -0.06965514813098012 3 7 0.41590561401882165 0 epithelial_barrier_identity observed_partial_RNA_mixture strict20_healthy_age 8 5 3 descriptive_only -0.1668156027103908 2 6 0.8291047719205996 0 epithelial_barrier_identity observed_partial_RNA_mixture strict20_healthy_age_sex_version 8 5 3 descriptive_only -0.15992737256359868 4 4 0.9427803379416286 0 epithelial_barrier_identity common_RNA_weight_partial_mixture all_healthy_age 13 10 3 descriptive_only -0.05405366916825565 2 11 0.3782303370786517 -0.0762505825716789 -0.03244969839586981 13 0 epithelial_barrier_identity common_RNA_weight_partial_mixture all_healthy_age_sex_version 13 10 3 descriptive_only -0.03444073125635272 4 9 0.40759578758682535 -0.06566132366210004 -0.016534124051006724 13 0 epithelial_barrier_identity common_RNA_weight_partial_mixture female_healthy_age_version 10 10 0 descriptive_only -0.026851093206602117 3 7 0.41590561401882165 0 epithelial_barrier_identity common_RNA_weight_partial_mixture strict20_healthy_age 8 5 3 descriptive_only -0.06983957201159982 2 6 0.8291047719205996 0 epithelial_barrier_identity common_RNA_weight_partial_mixture strict20_healthy_age_sex_version 8 5 3 descriptive_only -0.05128842007476808 4 4 0.9427803379416286 0 epithelial_barrier_identity lineage_reference_same_donors all_healthy_age 13 10 3 descriptive_only -0.050385885288158266 2 11 0.3782303370786517 -0.07848510755778956 -0.03126808869374137 13 0 epithelial_barrier_identity lineage_reference_same_donors all_healthy_age_sex_version 13 10 3 descriptive_only -0.02467262033639181 4 9 0.40759578758682535 -0.06202828888131 0.005597511442016062 13 1 epithelial_barrier_identity lineage_reference_same_donors female_healthy_age_version 10 10 0 descriptive_only -0.02169043166407822 3 7 0.41590561401882165 0 epithelial_barrier_identity lineage_reference_same_donors strict20_healthy_age 8 5 3 descriptive_only -0.08558586209448035 2 6 0.8291047719205996 0 epithelial_barrier_identity lineage_reference_same_donors strict20_healthy_age_sex_version 8 5 3 descriptive_only -0.0664455670559976 4 4 0.9427803379416286 0 fibroblast_stromal_identity observed_partial_RNA_mixture all_healthy_age 13 10 3 descriptive_only 0.151269062154017 2 11 0.3782303370786517 0.07891371759088724 0.2003419653702371 13 0 fibroblast_stromal_identity observed_partial_RNA_mixture all_healthy_age_sex_version 13 10 3 descriptive_only 0.14269593749657034 4 9 0.40759578758682535 0.06551884654394483 0.21530158212678752 13 0 fibroblast_stromal_identity observed_partial_RNA_mixture female_healthy_age_version 10 10 0 descriptive_only 0.13783925855457785 3 7 0.41590561401882165 0 fibroblast_stromal_identity observed_partial_RNA_mixture strict20_healthy_age 8 5 3 descriptive_only 0.24568385934835463 2 6 0.8291047719205996 0 fibroblast_stromal_identity observed_partial_RNA_mixture strict20_healthy_age_sex_version 8 5 3 descriptive_only 0.2118804784354178 4 4 0.9427803379416286 0 fibroblast_stromal_identity common_RNA_weight_partial_mixture all_healthy_age 13 10 3 descriptive_only 0.12451344594684025 2 11 0.3782303370786517 0.066199966189808 0.14703979114736812 13 0 fibroblast_stromal_identity common_RNA_weight_partial_mixture all_healthy_age_sex_version 13 10 3 descriptive_only 0.1516811006548898 4 9 0.40759578758682535 0.083839324924556 0.20768031486876698 13 0 fibroblast_stromal_identity common_RNA_weight_partial_mixture female_healthy_age_version 10 10 0 descriptive_only 0.15573383798181908 3 7 0.41590561401882165 0 fibroblast_stromal_identity common_RNA_weight_partial_mixture strict20_healthy_age 8 5 3 descriptive_only 0.0740791849788795 2 6 0.8291047719205996 0 fibroblast_stromal_identity common_RNA_weight_partial_mixture strict20_healthy_age_sex_version 8 5 3 descriptive_only 0.08486136906659339 4 4 0.9427803379416286 0 fibroblast_stromal_identity lineage_reference_same_donors all_healthy_age 13 10 3 descriptive_only 0.11842484937316959 2 11 0.3782303370786517 0.05768619769222557 0.13686033821341753 13 0 fibroblast_stromal_identity lineage_reference_same_donors all_healthy_age_sex_version 13 10 3 descriptive_only 0.1510137763205072 4 9 0.40759578758682535 0.08039667686706217 0.20250203675896677 13 0 fibroblast_stromal_identity lineage_reference_same_donors female_healthy_age_version 10 10 0 descriptive_only 0.1555034044270537 3 7 0.41590561401882165 0 fibroblast_stromal_identity lineage_reference_same_donors strict20_healthy_age 8 5 3 descriptive_only 0.04092666572591891 2 6 0.8291047719205996 0 fibroblast_stromal_identity lineage_reference_same_donors strict20_healthy_age_sex_version 8 5 3 descriptive_only 0.058004989506023785 4 4 0.9427803379416286 0