Tissue delivery / Source audit with conditional calculations

See reported association comparisons

Delivery signals depend on time and reporter history

No new fit, raw paired animal series, intended-cell fraction or repair outcome is supplied. Reporter area retains prior activity, and three image fields do not establish three independent animals. Rounding bounds are not confidence intervals.

Source: studies/checklist-engineering-2026-10-22/delivery/results.json
SHA-256 of UTF-8 text with LF line endings: 57f50f4fc13985381da540871aaa092c86bcc232dd38ba05dc83ae85b8741e53

{
  "evidence_kind": "source_summary_analysis",
  "source_doi": "10.1038/s41467-025-68103-7",
  "source_figure": "Figure 2",
  "annotation_count": 6,
  "within_formulation_organ_comparisons": [
    {
      "formulation_label": "Liver SORT",
      "target_organ": "liver",
      "early_panel": "2d",
      "late_panel": "2e",
      "reported_r_squared_1h": 0.97,
      "reported_r_squared_24h": 0.93,
      "early_association_time_pair_h": {
        "qpcr": 1,
        "reporter": 24
      },
      "late_association_time_pair_h": {
        "qpcr": 24,
        "reporter": 24
      },
      "reported_difference_1h_minus_24h": 0.04,
      "display_rounding_difference_enclosure": [
        0.03,
        0.05
      ],
      "earlier_association_higher_under_rounding_assumption": true,
      "unit": "Difference of dimensionless reported R-squared summaries",
      "individual_pairing": "Unavailable; not inferred from matched group labels"
    },
    {
      "formulation_label": "Lung SORT",
      "target_organ": "lung",
      "early_panel": "2i",
      "late_panel": "2j",
      "reported_r_squared_1h": 0.92,
      "reported_r_squared_24h": 0.87,
      "early_association_time_pair_h": {
        "qpcr": 1,
        "reporter": 24
      },
      "late_association_time_pair_h": {
        "qpcr": 24,
        "reporter": 24
      },
      "reported_difference_1h_minus_24h": 0.05,
      "display_rounding_difference_enclosure": [
        0.04,
        0.06
      ],
      "earlier_association_higher_under_rounding_assumption": true,
      "unit": "Difference of dimensionless reported R-squared summaries",
      "individual_pairing": "Unavailable; not inferred from matched group labels"
    },
    {
      "formulation_label": "Spleen SORT",
      "target_organ": "spleen",
      "early_panel": "2n",
      "late_panel": "2o",
      "reported_r_squared_1h": 0.98,
      "reported_r_squared_24h": 0.86,
      "early_association_time_pair_h": {
        "qpcr": 1,
        "reporter": 24
      },
      "late_association_time_pair_h": {
        "qpcr": 24,
        "reporter": 24
      },
      "reported_difference_1h_minus_24h": 0.12,
      "display_rounding_difference_enclosure": [
        0.11,
        0.13
      ],
      "earlier_association_higher_under_rounding_assumption": true,
      "unit": "Difference of dimensionless reported R-squared summaries",
      "individual_pairing": "Unavailable; not inferred from matched group labels"
    }
  ],
  "comparison_count": 3,
  "earlier_higher_count_under_rounding_assumption": 3,
  "rounding_enclosure_meaning": "Display precision only. Neither statistical uncertainty nor a confidence interval.",
  "new_correlation_fit": false,
  "association_difference_significance": null,
  "out_of_sample_prediction_error": null,
  "independent_animal_n_from_image_fields": null,
  "source_reported_discordance": {
    "condition": "Liver SORT",
    "early_qpcr_time_h": 1,
    "early_qpcr_predominant_organ": "liver",
    "late_qpcr_time_h": 24,
    "late_qpcr_predominant_organ": "spleen",
    "reporter_time_h": 24,
    "reporter_predominant_organ": "liver",
    "evidence": "Main results discussion of Figure2 and SupplementaryFigure3j; source-described organ preference, not a re-estimated quantitative specificity ratio",
    "cross_animal_pairing": null
  },
  "unavailable_endpoints": {
    "intact_full_length_cargo_fraction": null,
    "individual_animal_qpcr_reporter_pairing": null,
    "intended_cell_uptake_fraction": null,
    "intended_cell_functional_coverage_fraction": null,
    "causal_lesion_corrected_fraction": null,
    "disease_functional_repair": null,
    "human_oral_availability": null,
    "rejuvenation": null
  }
}