Dental restoration / Published data reanalysis

See descriptive source-summary ratios

Oral tissue thickness, resistance and tracer transport differ

These are aggregate summaries with reported SEM and replicate counts, not paired donor/insert effects. Commercial total thickness includes matrix. The narrowed noninfectious comparison does not establish native gingival restoration.

Source: studies/checklist-engineering-2026-10-22/barrier/results.json
SHA-256 of UTF-8 text with LF line endings: 3f3218bd6349350ba5e7d2eedb6054a33ca0b0f74a39b1611b4797ada314088d

{
  "schema_version": 1,
  "evidence_kind": "descriptive_source_summary_comparison",
  "source_doi": "10.1021/acs.molpharmaceut.4c01186",
  "model_summary_count": 4,
  "independent_donor_count": null,
  "comparison_ali_over_submerged": {
    "numerator": "ALI",
    "denominator": "Submerged",
    "thickness_ratio_of_reported_means": 7.542857142857143,
    "teer_ratio_of_reported_means": 1.0161290322580645,
    "paired_insert_effect": null,
    "confidence_interval": null,
    "fd20_papp_ratio_of_reported_coefficients": 0.577319587628866,
    "fd20_papp_relative_difference_percent": -42.268041237113394
  },
  "comparison_full_thickness_over_microtissue": {
    "numerator": "Hu-FT",
    "denominator": "Hu-Mic",
    "thickness_ratio_of_reported_means": 8.941176470588236,
    "teer_ratio_of_reported_means": 0.8560975609756097,
    "paired_insert_effect": null,
    "confidence_interval": null
  },
  "teer_blank_subtraction": "source states R_cells minus R_blank, multiplied by insert growth area",
  "tr146_insert_area_cm2": 0.336,
  "direct_permeability_evidence": "reported FD20 apparent permeability only; not inferred from TEER or thickness",
  "clinical_equivalence": null,
  "joint_thickness_teer_transport_per_insert": null,
  "gingival_restoration_outcome": null,
  "source_facts_sha256": "ae4ea478d87ec12495f5bd4b937dd102c8a1b11835cd752fcdbfcd5bd0d08812"
}