Dental restoration / Observational data reanalysis
See the recorded endpoint patterns
Living-pulp records retain sensory and imaging discordance
This is an uncontrolled five-patient measured pattern, not a regeneration success rate. MRI signal is not blood flow, late responses stay at their later visit, and CBCT timing/unit conflicts remain unresolved.
{
"evidence_kind": "Observed patient-linked pilot-study endpoint patterns, not complete pulp regeneration",
"patient_registry": {
"enrolled": 5,
"one_affected_tooth_per_patient": true,
"screened_or_approached": null,
"Table4_24wk_EPT_status_records": 5,
"Table4_24wk_apical_MRI_values": 5,
"Table4_24wk_XR_symbols": 5,
"unambiguous_binary_XR_radiolucency_states": 4,
"Table4_CBCT_flags_with_unspecified_visit": 5,
"same_unit_numeric_CBCT_volume_pairs": 1,
"reported_formal_dropout_flow": null,
"complete36wk_cohort_inferred": false
},
"EPT_source_status_counts": {
"onset_EPT_table4": {
"denominator_enrolled_patients": 5,
"observed_pattern_patient_ids": [
"1",
"3",
"4",
"5"
],
"observed_not_pattern_patient_ids": [
"2"
],
"unknown_patient_ids": [],
"count_bounds": [
4,
4
],
"proportion_bounds": [
0.8,
0.8
],
"meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
},
"EPT_12wk_table4": {
"denominator_enrolled_patients": 5,
"observed_pattern_patient_ids": [
"1",
"3",
"4",
"5"
],
"observed_not_pattern_patient_ids": [
"2"
],
"unknown_patient_ids": [],
"count_bounds": [
4,
4
],
"proportion_bounds": [
0.8,
0.8
],
"meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
},
"EPT_24wk_table4": {
"denominator_enrolled_patients": 5,
"observed_pattern_patient_ids": [
"1",
"3",
"4",
"5"
],
"observed_not_pattern_patient_ids": [
"2"
],
"unknown_patient_ids": [],
"count_bounds": [
4,
4
],
"proportion_bounds": [
0.8,
0.8
],
"meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
}
},
"EPT_reading_audit": {
"nested_device_readings": 36,
"independent_patients": 5,
"right_censored_readings": [
{
"patient_id": "4",
"source_endpoint": "onset_EPT_table4",
"source_token": "80+"
},
{
"patient_id": "5",
"source_endpoint": "onset_EPT_table4",
"source_token": "80+"
}
],
"changed_control_tooth_patient_ids": [
"1",
"3",
"4"
],
"normalized_longitudinal_sensory_recovery_percent": null,
"interpretation": "Source categorical positivity only; device units are not linear nerve function. No averaging80+ as80 or averaging across changing control teeth."
},
"MRI_24wk_apical_signal": {
"patient_values": [
{
"patient_id": "1",
"relative_signal": 0.8
},
{
"patient_id": "2",
"relative_signal": 0.9
},
{
"patient_id": "3",
"relative_signal": 0.9
},
{
"patient_id": "4",
"relative_signal": 0.7
},
{
"patient_id": "5",
"relative_signal": 0.9
}
],
"source_ratio_definition": "Ratio of root-canal tissue signal to surrounding dentin, compared with normal pulp/dentin in the opposite site; apical Table4 values only. No healthy threshold adopted.",
"mean": 0.84,
"median": 0.9,
"minimum": 0.7,
"maximum": 0.9,
"source_defined_healthy_threshold": null,
"direct_blood_flow": null,
"native_pulp_identity_confirmed": null,
"interpretation": "Continuous relative image signal, not perfusion, normal-tissue equivalence or a histological identity test"
},
"linked_measured_patterns": {
"EPT_positive_at_both12_and24_weeks": {
"denominator_enrolled_patients": 5,
"observed_pattern_patient_ids": [
"1",
"3",
"4",
"5"
],
"observed_not_pattern_patient_ids": [
"2"
],
"unknown_patient_ids": [],
"count_bounds": [
4,
4
],
"proportion_bounds": [
0.8,
0.8
],
"meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
},
"24wk_EPT_positive_and_MRI_value_available": {
"denominator_enrolled_patients": 5,
"observed_pattern_patient_ids": [
"1",
"3",
"4",
"5"
],
"observed_not_pattern_patient_ids": [
"2"
],
"unknown_patient_ids": [],
"count_bounds": [
4,
4
],
"proportion_bounds": [
0.8,
0.8
],
"meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
},
"24wk_MRI_value_available_and_unambiguous_XR_radiolucency_absence": {
"denominator_enrolled_patients": 5,
"observed_pattern_patient_ids": [
"1",
"3",
"5"
],
"observed_not_pattern_patient_ids": [
"4"
],
"unknown_patient_ids": [
"2"
],
"count_bounds": [
3,
4
],
"proportion_bounds": [
0.6,
0.8
],
"meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
},
"24wk_EPT_positive_MRI_value_available_and_unambiguous_XR_radiolucency_absence": {
"denominator_enrolled_patients": 5,
"observed_pattern_patient_ids": [
"1",
"3",
"5"
],
"observed_not_pattern_patient_ids": [
"2",
"4"
],
"unknown_patient_ids": [],
"count_bounds": [
3,
3
],
"proportion_bounds": [
0.6,
0.6
],
"meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
},
"24wk_EPT_positive_with_XR_radiolucency_present": {
"denominator_enrolled_patients": 5,
"observed_pattern_patient_ids": [
"4"
],
"observed_not_pattern_patient_ids": [
"1",
"2",
"3",
"5"
],
"unknown_patient_ids": [],
"count_bounds": [
1,
1
],
"proportion_bounds": [
0.2,
0.2
],
"meaning": "Exact finite-cohort identification bounds from reported categorical observations; no confidence interval, causal benefit or biological regeneration criterion"
}
},
"MRI_availability_in_patterns": "All5 have a numeric Table4 ratio. Availability is not an MRI-positive or physiological-success classification.",
"discordant_patient_records": [
{
"patient_id": "2",
"EPT_24wk_positive": false,
"apical_MRI_ratio": 0.9,
"XR_radiolucency": "Unresolved minus/plus, shrinking prior lesion and widened PDL; not coded absent",
"late_EPT": "After36weeks footnote only; exact time and complete later cohort unavailable"
},
{
"patient_id": "4",
"EPT_24wk_positive": true,
"apical_MRI_ratio": 0.7,
"XR_radiolucency": "Present at24weeks following PDL widening at12weeks; no causal attribution computed",
"CBCT": "Positive lateral-mineralization flag at an unassigned Table4 visit; not a24-week joint criterion"
}
],
"CBCT_separate_source_flags": {
"reported_lateral_mineralization_patient_ids": [
"1",
"4",
"5"
],
"denominator_enrolled_patients": 5,
"exact_visit_in_Table4": null,
"native_dentin_or_mechanical_strength_confirmed": null,
"volume_audits": [
{
"patient_id": "1",
"before_value": 0.0143,
"before_unit_literal": "cm3",
"after_value": 0.0125,
"after_unit_literal": "cm3",
"results_narrative_times_weeks": [
16,
28
],
"timing_qualification": "Results narrative16/28weeks; no individual acquisition dates given",
"endpoint": "CBCT threshold-defined low-density pulp-space volume, not direct tissue mass, perfusion or histological dentin volume",
"eligible_for_24wk_joint_pattern": false,
"status": "same_unit_printed_pair",
"decrease_value": 0.0017999999999999995,
"decrease_fraction": 0.12587412587412583
},
{
"patient_id": "4",
"before_value": 0.011,
"before_unit_literal": "cm3",
"after_value": 0.0081,
"after_unit_literal": "m3",
"results_narrative_times_weeks": [
16,
28
],
"timing_qualification": "Figure3b labels16 and28/32weeks; patient4 Discussion instead mentions12/24weeks",
"endpoint": "CBCT threshold-defined low-density pulp-space volume, not direct tissue mass, perfusion or histological dentin volume",
"eligible_for_24wk_joint_pattern": false,
"status": "source_unit_conflict",
"decrease_value": null,
"decrease_fraction": null,
"interpretation": "No unit repair or conditional change computed; source unit/time conflicts remain unresolved"
}
],
"missing_initial_CBCT_patient5": true,
"cohort_mean_volume_change": null
},
"safety_and_limits": {
"source_reports_no_attributed_systemic_or_clinical_events_through24wk": true,
"source_lab_clinical_abnormality_symbols": {
"1": {
"Blood test": "\u2013",
"Urine test": "\u2013",
"Cardiogram": "\u2013",
"Local clinical examination": "\u2013"
},
"2": {
"Blood test": "\u2013",
"Urine test": "\u2013",
"Cardiogram": "\u2013",
"Local clinical examination": "\u2013"
},
"3": {
"Blood test": "\u2013",
"Urine test": "\u2013",
"Cardiogram": "\u2013",
"Local clinical examination": "\u2013"
},
"4": {
"Blood test": "\u2013",
"Urine test": "\u2013",
"Cardiogram": "\u2013",
"Local clinical examination": "\u2013"
},
"5": {
"Blood test": "\u2013",
"Urine test": "\u2013",
"Cardiogram": "\u2013",
"Local clinical examination": "\u2013"
}
},
"new_patient4_radiographic_abnormality_preserved": true,
"cell_karyotype_patterns_not_all_declared_normal": true,
"long_term_safety_proven": false,
"controlled_treatment_effect": null,
"full_regeneration_success_count": null,
"directly_measured_perfusion_or_human_pulp_histology_n": 0
}
}